Publication focus: high quality genome-wide genotyping from archived dried blood spots without DNA amplification

High Quality Genome-Wide Genotyping from Archived Dried Blood Spots without DNA Amplification
Krystal R. St. Julien et al. PLoS ONE, May 2013, 8(5): e64710. doi:10.1371/journal.pone.0064710

Abstract

Spots of blood are routinely collected from newborn babies onto filter paper called Guthrie cards and used to screen for metabolic and genetic disorders. The archived dried blood spots are an important and precious resource for genomic research. Whole genome amplification of dried blood spot DNA has been used to provide DNA for genome-wide SNP genotyping.

Ready To Go and its role in the future of molecular diagnostics

In general, any process that has requirements for a cold-chain or applications with a requirement to reduce the complexity of the [molecular diagnostic] assay could benefit from Ready-To-Go [ambient temperature assay stabilisation].

Stabilisation of biological assays and molecular diagnostics

We see increasing use of ambient temperature stabilisation of biological assays in two main areas. 

Publication focus: Whatman FTA and HPV genotyping

Agreement for HPV genotyping detection between self-collected specimens on a FTA cartridge and clinician-collected specimens.Guan Y. et al. J Virol Methods. 2013 Apr;189(1):167-71.

Abstract

The current method of transporting self-collected cervicovaginal specimen for HPV DNA testing relies on liquid based medium, which is challenging and expensive to transport.

Technology pulse 2: Towards more effective healthcare - a compelling study.

A recent article by Racey et. al., titled “Self-collect HPV Testing Improves Participation in Cervical Cancer Screening: A Systemic Review and Meta-analysis”¹ addressed an often challenging question of how to increase the effectiveness and reach of screening programs.